I played around with gearing the bike longer so that the revs would drop at motorway speeds. I found that there's practically no difference in fuel economy, but if you get it right the vibrations are reduced and you have a more comfortable ride. The trade off is less acceleration in the lower gears, but it's not so much as to be any kind of problem, particularly not if you're someone that spends a lot of time on motorways. I ended up going back to stock sprocket rations when my commute went down from ~185 miles per day to ~125 miles a day. I'd only go for longer gearing if I start doing some serious miles again, but even then I'd just go to a 45 on the rear instead of a 47, that was a good setup for me.